02 Details

BCR-ABL P210 ELITe MGB® Kit

The product of the Philadelphia translocation, the BCR/ABL oncogene P210 isoform, is typically found in chronic myelogenous leukemia, and in acute lymphoid and myeloid leukemia, causing the cells to divide uncontrollably and inducing severe outcomes among patients. Detection and quantification of P210 BCR-ABL fusion gene, by molecular methods, is crucial for patient management, to initiate the appropriate treatment, measure the response to therapy and predict relapse BCR-ABL P210 ELITe MGB® Kit is a real-time PCR assay for the quantification of the mRNA of the BCR-ABL rearrangement, t(9;22) translocation of the Philadelphia chromosome, isoform P210 compared to the mRNA of the gene coding the kinase protein Abelson (ABL) mRNA. The assay is validated on Mononuclear Cells from human Peripheral Blood or Bone Marrow in combination with ELITe InGenius®, a fully automated sample-to-result solution.

 

Benefits

Conserved targets
  • Fusion gene and BCR-ABL, isoform P210
  • Human gene ABL
One-step format
  • Reverse transcription and real-time PCR assay within the same run
Best-in class PCR technology
  • ELITe MGB probes designed with Minor Groove Binder, Superbases® and Eclipse® Dark Quencher
Large range of samples
  • Peripheral blood samples, medullary blood samples collected in citrate or EDTA, lymphomonocyte or leukocyte suspensions
Instruments
  • Fully automated process for extraction, amplification and result analysis with ELITe InGenius®
High performance
  • 97% clinical sensitivity and 95,1% clinical specificity

 

 

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